EUFLEXXA—Proven results to help keep you moving forward2,3

What results did EUFLEXXA have in patients with OA of the knee?

Study design: The effectiveness and safety of EUFLEXXA was shown to be comparable to another HA product in a head-to-head clinical trial. The study was conducted in 321 patients with OA knee pain over a 12-week period.2,3*

In a 12-week clinical trial, patients experienced2,3:

Powerful pain relief

Pain relief began as early as 1-week after the first injection and continued to improve after each one

Week After

1st INJECTION
(n=160)

19%

2nd INJECTION
(n=159)

37%

3rd INJECTION
(n=159)

48%

Mean change (%) from baseline WOMAC pain score.

Weeks After

55%
Synvisc

3rd INJECTION
(n=158)

62%
EUFLEXXA

3rd INJECTION
(n=157)

Both treatments showed meaningful improvements from baseline (P<0.0001).2,3

Nearly 2/3 of EUFLEXXA patients were PAIN-FREE at the end of the 12-week study3

Pain-free is defined as symptom-free for the 5 WOMAC pain questions (with average visual analog scale [VAS] scores of <20mm).

After 3 injections, patients had significantly less pain associated with 5 basic functions3†

Climbing Stairs

Walking

Standing

Sitting

Resting During Night

Less pain medication needed3‡

Patients treated with EUFLEXXA needed less pain medication compared to patients treated with another HA injection

Higher satisfaction3

Patients treated with EUFLEXXA were satisfied with the pain relief they experienced

Adverse Events

Most common adverse events in the clinical trial include joint pain (11/160), increase in blood pressure (3/160), joint swelling (3/160), feeling of sickness (3/160), tingling (2/160), back pain (1/160), nausea (1/160), skin irritation (1/160), tenderness in study knee (1/160).2,3

Please see additional Important Safety Information.

*Based on % reduction in Western Ontario and McMaster Universities Osteoarthritis Index pain score from baseline in a pivotal, 12-week trial of EUFLEXXA (n=157) vs Synvisc (n=158). Improvements from baseline were statistically significant for both treatment groups. EUFLEXXA = 101/160.

†Questions based on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). WOMAC is an internationally recognized and widely used set of standardized questionnaires that allow healthcare providers to assess the condition of patients with osteoarthritis of the knee and hip. Measures include pain, stiffness, and physical functioning of the joints.

‡Acetaminophen was the only additional medication provided.

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FAQs

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  1. Rolling 12 month average of IQVIA claims data based on unique patients (December 2022).
  2. EUFLEXXA [package insert]. Parsippany, NJ: Ferring Pharmaceuticals Inc.
  3. Kirchner M, Marshall D. A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 2006;14(2):154-162.

Please see Important Safety Information and Full Prescribing Information

Indication

EUFLEXXA (1% sodium hyaluronate) is used to relieve knee pain due to osteoarthritis. It is used for patients who do not get enough relief from simple pain medications such as acetaminophen or from exercise and physical therapy.

EUFLEXXA is only for injection into the knee, performed by a doctor or other qualified healthcare professional.

Important Safety Information

  • Do not take this product if you have had any previous allergic reaction to EUFLEXXA or hyaluronan products.
  • You should not have EUFLEXXA injected into the knee if you have a knee joint infection or skin diseases or infections around the injection site.
  • EUFLEXXA has not been tested in pregnant women, women who are nursing or in children less than 18 years of age. After you receive your EUFLEXXA injection you should avoid physical activities for 48 hours such as jogging, tennis, heavy lifting, or standing on your feet for a long time (more than one hour at a time.)
  • The most common adverse events related to EUFLEXXA injections were joint pain, back pain, limb pain, muscle pain, and joint swelling.

Please see full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

You may also contact Ferring Pharmaceuticals Inc. at 1-888-FERRING.

Indication

EUFLEXXA (1% sodium hyaluronate) is used to relieve knee pain due to osteoarthritis. It is used for patients who do not get enough relief from simple pain medications such as acetaminophen or from exercise and physical therapy.

EUFLEXXA is only for injection into the knee, performed by a doctor or other qualified healthcare professional.

Important Safety Information

  • Do not take this product if you have had any previous allergic reaction to EUFLEXXA or hyaluronan products.
  • You should not have EUFLEXXA injected into the knee if you have a knee joint infection or skin diseases or infections around the injection site.
  • EUFLEXXA has not been tested in pregnant women, women who are nursing or in children less than 18 years of age. After you receive your EUFLEXXA injection you should avoid physical activities for 48 hours such as jogging, tennis, heavy lifting, or standing on your feet for a long time (more than one hour at a time.)
  • The most common adverse events related to EUFLEXXA injections were joint pain, back pain, limb pain, muscle pain, and joint swelling.

Please see full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

You may also contact Ferring Pharmaceuticals Inc. at 1-888-FERRING.

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The content on this website is for informational purposes only and is not intended to replace a discussion with a healthcare professional.

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EUFLEXXA is covered on Medicare Part B*, and is covered by most private plans. Your healthcare provider’s office will check your benefits.

Your EUFLEXXA coverage certificate will let you know if you are covered. Bring your certificate to your doctor to discuss EUFLEXXA as a possible treatment option for you.

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This program assists in the determination of whether treatment could be covered by the applicable third-party payer based on coverage guidelines provided by the payer and patient information provided by you. Third-party reimbursement is affected by many factors. Therefore, we make no representation or guarantee that full or partial insurance reimbursement or any other payment will be available. This is not intended to be medical advice. Please consult with your healthcare provider to determine which treatment may be right for you.

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