What to Expect During and After Treatment

During your treatment with Euflexxa

  • Some people experience moderate pain relief after the 1st or 2nd injection of Euflexxa2
  • Most people experience significant relief after the 3rd (last) injection.2
  • For maximum pain relief, be sure to get all 3 injections.2
  • When it comes to duration of pain relief, each person is different. In general, 1 course of 3 Euflexxa injections has been shown to provide up to 6 months of knee pain relief.2
  • The most common adverse events related to Euflexxa injections were joint pain, back pain, limb pain, muscle pain, and joint swelling.2

After your Euflexxa injection

  • Avoid physical activity for 48 hours after receiving your EUFLEXXA injection
  • Ice your knee if you have any mild pain or swelling near the injection site
  • Avoid standing on your feet for more than 1 hour at a time during the first 48 hours following the injection
  • Ask your healthcare provider when you should begin major physical activities again
  • Call your healthcare provider immediately if you experience joint pain, back pain, limb/muscle pain, or joint swelling, or if you have any other problems

Download the full post-injection instructions guide

To ensure you are getting the most out of your treatment with Euflexxa, make sure you follow the below steps.

Did You Know?
If you have pain in both knees, also known as bilateral OA,
talk to your healthcare provider about getting 3 injections in each knee.2

*As shown in a 26-week multicenter, randomized, double-blind, saline-controlled study of 588 subjects (ITT populations) with OA knee pain.2

Frequently Asked Questions

Download the full FAQ or send to yourself by clicking on one of the links below

Does insurance cover EUFLEXXA

Find a physician near you who offers EUFLEXXA

This is not a complete list of all physicians in your area. Ferring is not responsible for the consistency and accuracy of the information provided. A listing on this site does not constitute a referral.

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If you have private health insurance

Good news! Most plans cover EUFLEXXA. Your healthcare provider’s office will check your benefits. If your plan doesn’t cover EUFLEXXA, your healthcare provider’s office will provide details on how you can buy EUFLEXXA directly. Payment can be made via FSA (flexible savings account), HSA (health savings account), credit card, or check.

If you have Medicare Part B

EUFLEXXA is covered 100% of the time.

Getting the most out of your treatment

If you are receiving EUFLEXXA or are considering starting EUFLEXXA soon, the HAppy Knees Program was made for you. Get informative lifestyle tips and information about EUFLEXXA via email and helpful appointment reminders via text. Sign up and we’ll communicate with you by email, text, or both. It’s your choice!

Please See Important Safety Information and Full Prescribing Information.


EUFLEXXA (1% sodium hyaluronate) is used to relieve knee pain due to osteoarthritis. It is used for patients who do not get enough relief from simple pain medications such as acetaminophen or from exercise and physical therapy.

EUFLEXXA is only for injection into the knee, performed by a doctor or other qualified healthcare professional.


  • Do not take this product if you have had any previous allergic reaction to EUFLEXXA or hyaluronan products.
  • You should not have EUFLEXXA injected into the knee if you have a knee joint infection or skin diseases or infections around the injection site.
  • EUFLEXXA has not been tested in pregnant women, women who are nursing or in children less than 18 years of age. After you receive your EUFLEXXA injection you should avoid physical activities for 48 hours such as jogging, tennis, heavy lifting, or standing on your feet for a long time (more than one hour at a time).
  • The most common adverse events related to EUFLEXXA injections were joint pain, back pain, limb pain, muscle pain, and joint swelling.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.
You may also contact Ferring Pharmaceuticals Inc. at 1-888-FERRING.