EUFLEXXA is a highly purified form of hyaluronic acid (HA). HA is a natural substance found in the synovial fluid that cushions, lubricates, and protects a healthy knee. In people with osteoarthritis of the knee, the synovial fluid becomes thinner and less able to do its job.1

EUFLEXXA is a natural, non-bird-derived HA similar to the HA found in healthy knees. When injected into the knee, it helps replenish the HA and restore the functioning of the synovial fluid.1,2

EUFLEXXA is designed to help patients who are not getting enough relief from nonprescription pain relievers or from exercise and physical therapy.1

EUFLEXXA is unlike pills that can irritate your digestive
system because it works right at the source of
pain and is not distributed throughout the body.1
How is EUFLEXXA given, and what can I expect from treatment?

EUFLEXXA is injected into the space in your knee joint. Treatment consists of 3 injections—1 injection per week for 3 weeks.1

Some people experience moderate pain relief after the first or second injection of EUFLEXXA, but most people experience significant relief after the third (last) injection. The approved dosing regimen for EUFLEXXA is 3 injections. Even if you experience pain relief after your first or second injection of EUFLEXXA, be sure to still get all 3 injections for maximum benefit.1,3

How long does EUFLEXXA last?

When it comes to the length of pain relief, every person is different. In general, 1 course of EUFLEXXA injections can give you months of pain relief. In clinical studies, EUFLEXXA gave most people up to 6 months of long-lasting pain relief.1,4

What important information should I know

Do not receive an injection of EUFLEXXA if you have had any previous allergic reaction to EUFLEXXA or other hyaluronan products. Do not have an injection into the knee if you have a knee joint infection or skin diseases or infections around the injection site.1

EUFLEXXA is only for injection into the knee, performed by a health- care professional. Try to avoid activities such as jogging, tennis, heavy lifting, or standing on your feet for a long time (more than 1 hour) for 2 days after receiving this injection.1

What side effects are seen with EUFLEXXA?

In clinical trials, few side effects were reported, and those that did occur tended to be mild. The most common side effects were pain in the knee or at the injection site and stiffness, swelling, or warmth in or around the knee.1,4,5

References: 1. EUFLEXXA [package insert]. Parsippany, NJ: Ferring Pharmaceuticals Inc; 2011. 2. Data on file. Bio-Technology General (Israel) Ltd. 3. Data on file. Ferring Pharmaceuticals Inc. 4. Altman RD, Rosen JE, Bloch DA, Hatoum HT, Korner P. A double-blind, randomized, saline-controlled study of the efficacy and safety of EUFLEXXA• for treatment of painful osteoarthritis of the knee, with an open-label safety extension (the FLEXX Trial). Semin Arthritis Rheum. 2009;39:1-9. 5. Kirchner M, Marshall D. A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 2006;14:154-162.

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