What is EUFLEXXA?

EUFLEXXA (1% sodium hyaluronate) is a hyaluronic acid (HA) product that is manufactured through a precise, multistep cleansing and filtering process that creates a highly purified, gel-like HA fluid. Unlike other HAs, EUFLEXXA is not derived from birds and is instead naturally created in a controlled environment. EUFLEXXA is designed for injection into the knee to help replace your knees own HA.1,2

WHEN EUFLEXXA IS INJECTED INTO THE KNEE, IT REPLENISHES
THE HA YOU’VE LOST, HELPING PROVIDE PAIN RELIEF.

WHAT DOES HYALURONIC ACID (HA) DO INSIDE YOUR KNEE AND WHY DOES IT NEED TO BE REPLACED?

HA is a natural substance that is found in the human body as well as in animals and bacteria. In the human knee, HA is a thick, slippery fluid that helps cushion, lubricate, and protect the bones and joint tissue. In patients with osteoarthritis (OA) of the knee, the HA gets thinner over time and becomes less able to provide protection.3

EUFLEXXA is used to relieve OA knee pain in people who do not get enough relief from simple pain medications such as acetaminophen, ibuprofen, or naproxen or from exercise and physical therapy.2

When EUFLEXXA is injected into the knee, it temporarily replenishes the HA you have lost while stimulating the knee to produce its own healthy HA.4,5 Clinical studies have shown that EUFLEXXA may help provide pain relief for up to 6 months.1-3,6-8

HOW IS EUFLEXXA GIVEN, AND WHAT CAN I EXPECT FROM TREATMENT?

EUFLEXXA is injected into the space in your knee joint. Treatment consists of 3 injections— 1 injection per week for 3 weeks.2

The approved dosing regimen for EUFLEXXA is 3 injections. Some people experience moderate pain relief after the first or second injection of EUFLEXXA, with most people experiencing significant relief after the third (last) injection. Even if you experience pain relief after your first or second injection of EUFLEXXA, be sure to still get all 3 injections for maximum benefit.2,5

HOW LONG DOES EUFLEXXA LAST?

When it comes to the length of pain relief, every person is different. In general, 1 course of EUFLEXXA injections may give you months of pain relief. In clinical studies, EUFLEXXA gave most people relief lasting up to 6 months.2,5,6

WHAT IMPORTANT INFORMATION SHOULD I KNOW ABOUT EUFLEXXA?

Do not get an injection of EUFLEXXA if you have had any previous allergic reaction to EUFLEXXA or other hyaluronan products. Do not get a EUFLEXXA injection into the knee if you have a knee joint infection or skin diseases or infections around the injection site.2

EUFLEXXA is only for injection into the knee and should be performed by a qualified healthcare professional. Try to avoid activities such as jogging, tennis, heavy lifting, or standing on your feet for a long time (more than 1 hour) for 2 days after receiving an injection.2

The safety and effectiveness of EUFLEXXA have not been established in pregnant women.

WHAT SIDE EFFECTS ARE SEEN WITH EUFLEXXA?

In clinical trials, the most common side effects were joint pain, back pain, limb pain, muscle pain, and joint swelling in the knee or at the injection site and stiffness, swelling, or warmth in or around the knee.2

If you feel knee pain, or if it’s worsening, print and bring this information to your doctor to guide
your discussion about whether EUFLEXXA is right for you.

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  • Step 3:
    Bring to your doctor and ask him or her about EUFLEXXA

References: 1. Data on file. Bio-Technology General (Israel) Ltd. 2. EUFLEXXA [package insert]. Parsippany, NJ: Ferring Pharmaceuticals Inc. 3. Benke M, Shaffer B. Viscosupplementation treatment of arthritis pain. Curr Pain Headache Rep. 2009;13(6):440-446. 4. Moreland LW. Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther. 2003;5:54-67. 5. Smith MM, Ghosh P. The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment. Rheumatol Int. 1987;7:113-122. 6. What is hyaluronic acid and how does it work for arthritis? Health Tuber website. http://www.healthtuber.com/Arthritis/what-is-hyaluronic-acid-and-how-does-it-work-for-arthritis.html. Accessed October 31, 2016. 7. Altman RD, Rosen JE, Bloch DA, Hatoum HT, Korner P. A double-blind, randomized, saline-controlled study of the efficacy and safety of EUFLEXXA® for treatment of painful osteoarthritis of the knee, with an open-label safety extension (the FLEXX Trial). Semin Arthritis Rheum. 2009;39(1):1-9. 8. Kirchner M, Marshall D. A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 2006;14(2):154-162.

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