Your treatment with EUFLEXXA

Sometimes osteoarthritis (OA) knee pain gets worse even when you do everything you’re supposed to do to help control your OA. Following all the tips for controlling your OA, such as eating right, maintaining a healthy weight, exercising, staying active, and taking your over-the-counter (OTC) and/or prescription pain relievers still may not relieve your pain well enough.

Only your doctor can tell you what type of treatment is right for you, and only your doctor can prescribe EUFLEXXA. This is why it’s so important to talk with him or her about your OA knee pain and ask whether EUFLEXXA is the right next therapy to help relieve your pain.

EUFLEXXA is a prescription-only therapy that is given by a doctor or other healthcare professional as a course of 3  injections— 1 injection a week for 3 weeks.2

CAN EUFLEXXA RELIEVE YOUR OA KNEE PAIN?

EUFLEXXA was studied in several clinical trials to determine how much it helps people like you who are experiencing pain, stiffness, or other symptoms caused by OA of the knee who had not received pain relief from other medications.

RESULTS FROM THE 12-WEEK STUDY  SHOWED2,3,*

  • Comparing patients’ overall knee pain before treatment with overall knee pain after 12 weeks, both EUFLEXXA and another HA provided similar improvement in pain reduction:
    • With EUFLEXXA, overall knee pain improved by an average of 62%
    • With the other HA, overall knee pain improved by an average of 55%

The bar graph shows improvement (reduction in pain score) for each therapy2,3,*:

  • Patients who received EUFLEXXA saw their pain score go from 49.2 before their injections down to 18.7 twelve weeks after the first injection
  • Patients who received another HA saw their pain score go from 51.9 before the injections down to 23.2 twelve weeks after the first injection

The most common adverse events related to EUFLEXXA injections were joint pain, back pain, limb pain, muscle pain, and joint swelling2

In the 12-week study, side effects caused by EUFLEXXA were joint pain (11/160), increase in blood pressure (3/160), joint swelling (3/160), feeling of sickness (3/160), tingling (2/160), back pain (1/160), nausea (1/160), skin irritation (1/160), and tenderness in study knee (1/160).

ONLY YOUR DOCTOR CAN TELL YOU WHAT TYPE OF TREATMENT
IS RIGHT FOR YOU, AND ONLY YOUR DOCTOR CAN PRESCRIBE EUFLEXXA.

MORE PATIENTS SAID THEY WERE VERY SATISFIED WITH EUFLEXXA3,* 

  • Both EUFLEXXA and the other HA satisfied a similar number of patients at the end of the 12-week study
  • With EUFLEXXA, MORE patients said they were VERY satisfied

THE PRIMARY ENDPOINT FROM THE 26-WEEK STUDY SHOWED EUFLEXXA WAS ABLE TO

  • Help people with knee pain get lasting pain relief for up to 6 months2,4,*
  • EUFLEXXA provided up to 6 months of pain relief for people with OA of the knee and provided noticeably better relief compared with salt water injections2,4,* 

A CONTINUATION OF THE STUDY SHOWED THAT A REPEAT TREATMENT WITH EUFLEXXA WAS SAFE FOR AN ADDITIONAL 26 WEEKS2,4,5,*,† 

—With an additional 3-injection course of EUFLEXXA given after 6 months, no patients experienced severe swelling caused by fluid buildup in the joint during the 1 year studied

*Individual results may vary.

All 516 patients who completed the 26-week FLEXX Trial were offered treatment with EUFLEXXA 26 weeks after their first treatment. For those patients who received a series of 3 salt water injections in the FLEXX Trial, this was their first 3-injection treatment with EUFLEXXA. For those who had previously received EUFLEXXA in the FLEXX Trial, this was a repeated series of 3 injections.5

WHAT MAKES EUFLEXXA DIFFERENT FROM THE OTHER PAIN RELIEVERS YOU MAY HAVE STARTED WITH?

  • EUFLEXXA is injected into your knee to treat OA knee pain right at the source.It is different from oral medication, which circulates throughout your body
  • EUFLEXXA is made from a natural, nonbird-derived source. This means that EUFLEXXA can be used in people who are allergic to poultry products1
  • EUFLEXXA is not processed with formaldehyde, vinyl sulfone, or cinnamic acid additives1,2,5

EUFLEXXA MAY NOT BE AN OPTION FOR YOU IF YOU HAVE1

  • A known allergy to hyaluronate products
  • A knee joint infection
  • An infection or skin disease around the area where EUFLEXXA would be administered

References:  1. Wieland HA, Michaelis M, Kirschbaum BJ, Rudolphi KA. Osteoarthritis— an untreatable disease? Nat Rev Drug Discov. 2005;4(4):331-344. 2. EUFLEXXA [package insert]. Parsippany, NJ: Ferring Pharmaceuticals Inc. 3. Kirchner M, Marshall D. A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 2006;14(2):154-162. 4. Altman RD, Rosen JE, Bloch DA, Hatoum HT, Korner P. A double-blind, randomized, saline-controlled study of the efficacy and safety of EUFLEXXA for treatment of painful osteoarthritis of the knee, with an open-label safety extension (the FLEXX Trial). Semin Arthritis Rheum. 2009;39(1):1-9. 5. Altman RD, Rosen JE, Bloch DA, Hatoum HT. Safety and efficacy of retreatment with a bioengineered hyaluronate for painful osteoarthritis of the knee: results of the open-label Extension Study of the FLEXX Trial. Osteoarthritis Cartilage. 2011;19(10):1169-1175.

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